Floris Klumpers received his PhD at Utrecht University on work on inter-individual differences in the neurobiology of anxiety and then moved to the Donders Institute to work as a post-doc on the impact of stress on affective neural circuity and memory. Currently he’s an assistant professor at the Behavioural Science Institute and the Donders Centre for Cognitive Neuroimaging. His main research interest is explaining individual differences in behaviour by studying the neurobiology of emotion. To this end, he studies psychopharmacological, genetic and psychophysiological pathways mediating individual differences in anxiety. As main tools he uses novel fear conditioning and stress induction methods combined with assessments of autonomic and somatic markers (startle, HR, SCR) and functional neuroimaging. At EPAN lab, he works on creating a bridge towards more clinically oriented work through a large-scale longitudinal project on stress-related resilience in police officers. In addition, he currently works on the integration of traditional fear conditioning measures with active behavioural measures of approach/avoidance to model costly avoidance behaviour and it’s psychophysiological origins.
Publications::
Vogel S, Klumpers F, Schröder TN, Oplaat KT, Krugers HJ, Oitzl MS, Joëls M, Doeller CF, Fernández G. (in press). Stress Induces a Shift Towards Striatum-Dependent Stimulus-Response Learning via The Mineralocorticoid Receptor. Neuropsychopharmacol
Voogd, L.D. de, Klumpers, F., Fernandez, G.S.E. & Hermans, E.J. (2017). Intrinsic functional connectivity between amygdala and hippocampus during rest predicts enhanced memory under stress.Psychoneuroendocrinology. pdf.
Berkers RM, Klumpers F, Fernández G. (2016) Medial prefrontal-hippocampal connectivity during emotional memory encoding predicts individual differences in the loss of associative memory specificity. Neurobiology of Learning & Memory. pdf.
Everaerd D, Klumpers F, Zwiers M, Guadalupe T, Franke B, van Oostrom I, Schene A, Fernández G, Tendolkar I. (2016). Childhood abuse and deprivation are associated with distinct sex-dependent differences in brain morphology. Neuropsychopharmacology. pdf.
Henckens MJ, Klumpers F, Everaerd D, Kooijman SC, van Wingen GA, Fernández G. (2016). Interindividual differences in stress sensitivity: basal and stress-induced cortisol levels differentially predict neural vigilance processing under stress. Social, Cognitive and Affective Neuroscience. pdf.
Everaerd DS, Klumpers F, van Wingen G, Tendolkar I, Fernández G. (2016). Author’s response to commentary ‘Depressive symptomatology should be systematically controlled for in neuroticism research’. Neuroimage. pdf.
Klumpers F, Morgan B, Terburg D, van Honk J (2015). Impaired acquisition of classically conditioned fear-potentiated startle reflexes in humans with focal bilateral basolateral amygdala damage. Social, Cognitive and Affective Neuroscience. pdf.
Vogel S, Klumpers F, Krugers HJ, Fang Z, Oplaat KT, Oitzl M, Joëls M & Fernández G (2015). A Stress-Induced Shift from Trace to Delay Conditioning Depends on the Mineralocorticoid Receptor. Biological Psychiatry. pdf.
Klumpers F, Kroes MC, Heitland I, Akkermans SEA, Oosting RS, van Wingen G, Franke B, Kenemans JL, Fernandez G & Baas JMP (2015). The 5-HTTLPR polymorphism is consistently associated with anxiety-related activity in the dorsomedial prefrontal cortex. Biological Psychiatry. pdf.
Klumpers F. De dorsomediale prefrontale cortex medieert genetisch bepaalde verschillen in angst (2015). Tijdschrift voor Psychiatrie. pdf.
Vogel S, Klumpers F, Krugers HJ, Fang Z, Oplaat KT, Oitzl M, Joëls M & Fernández G (2015). Blocking the mineralocorticoid receptor in humans prevents the stress-induced enhancement of centromedial amygdala connectivity with the dorsal striatum. Neuropsychopharmacol
Everaerd D, Klumpers F, van Wingen G, Tendolkar I, Fernández G (2015). Association between neuroticism and amygdala responsivity emerges under stressful conditions. Neuroimage. pdf.
Baas JMP, Klumpers F, Mantione M, Figee M, Vulink N, Schuurman R, Mazaheri A, & Denys D (2014). No impact of deep brain stimulation on fear-potentiated startle in obsessive-compulsive disorder. Frontiers in Behavioural Neuroscience. pdf.
Van der Knaap NJF, El Marroun H, Klumpers F, Homberg JR, White TJH, Tiemeier H & Fernandez G (2014). Beyond classical heritability, the influence of maternal genotype upon child’s brain morphology and behavior. Journal of Neuroscience. pdf.
Luo Y, Qin S, Fernandez G, Zhang Y, Klumpers F, Li H (2014) Dual competition of emotion perception and executive control in the salience network during emotional working memory processing. Human Brain Mapping. pdf.
Klumpers F, Denys D, Kenemans JL, Grillon C, van der Aart J, Olivier B & Baas JMP (2012). Testing the effects of δ-9 THC and D-cycloserine on the Extinction of Conditioned Fear in Humans. Journal of Psychopharmacology. pdf.
Heitland I, Klumpers F, Oosting RS, Evers DJ, Kenemans JL & Baas, JMP (2012). Failure to extinguish fear and genetic variability in the human cannabinoid receptor 1. Translational Psychiatry. pdf.
Klumpers F, Heitlandt I, Oosting R, Kenemans JL & Baas JMP (2012). Genetic variation in serotonin transporter function affects human fear expression indexed by fear-potentiated startle. Biological Psycholology. pdf.
Klumpers F, Raemaekers MAHL, Ruigrok NV, Hermans EJ, Kenemans JL & Baas JMP (2010): Prefrontal mechanisms of fear reduction after threat offset. Biological Psychiatry. pdf.
Klumpers F, van Gerven J, Prinssen EP, Niklson I, Roesch F, Riedel W, Kenemans JL & Baas JMP (2010). Method development studies for repeatedly measuring anxiolytic drug effects in healthy humans. Journal of Psychopharmacology. pdf.
Koolschijn PC, van Haren NE, Cahn W, Schnack HG, Janssen J, Klumpers F, Hulshoff Pol HE & Kahn RS (2010).Hippocampal volume change in schizophrenia. Journal of Clinical Psychiatry. pdf.