In this project we study the development of emotion regulation using unique prospective longitudinal studies including the Nijmegen Longitudinal Study (NLS) and the BIBO study, particularly focusing on the FPl-amygdala circuit, pubertal hormones, stress and links with psychopathology. Bridging animal and human studies by modelling neuro-hormonal trajectories across adolescence in humans, we recently identified within-individual changes in testosterone’s impact on neural emotion regulation, providing insight how neuro-hormonal processes mature (Tyborowska et al, 2024). In addition, we are currently testing the effects of acute hormonal fluctuations during the menstrual cycle on neuro-behavioral underpinnigs of emotion regulation as well as
Project group: Anna Tyborowska, Eliana Vassena, Maria Andrikopoulou and Marta Gomez Vargas (with Toon Cillessen, Caroline de Weerth, Maaike Cima and Danique Smeijers)
Selected publications:
Tyborowska A, Volman I, Niermann HCM, Dapprich AL, Smeekens S, Cillessen AHN, Toni I, Roelofs K. (2024). Developmental shift in testosterone influence on prefrontal emotion control. Dev Sci. 27(1):e13415. doi: 10.1111/desc.13415.
Tyborowska, A.B., Berg, Y.H.M. van den, Hashemi, M.M., Niermann, H.C.M., Cillessen, A.H.N., Toni, I. & Roelofs, K. (2023). Neural patterns of threat response in adolescents predict vulnerability for and resilience against internalizing symptoms during COVID-19 waves. NeuroImage: Reports, 3 (3):100177. doi: https://doi.org/10.1016/j.ynirp.2023.100177
Tyborowska A, Volman I, Niermann HCM, Pouwels JL, Smeekens S, Cillessen AHN, Toni I, Roelofs K. (2018). Early-life and pubertal stress differentially modulate grey matter development in human adolescents. Nature Sci Rep. 8(1):9201. doi: 10.1038/s41598-018-27439-5.
Tyborowska A, Volman I, Smeekens S, Toni I, Roelofs K. (2016). Testosterone during Puberty Shifts Emotional Control from Pulvinar to Anterior Prefrontal Cortex. J Neurosci. 36(23):6156-64. doi: 10.1523/JNEUROSCI.3874-15.2016.